March 2025

Enzymes for Innovation Graduates:
Driving Discovery Forward

What is an Enzyme for Innovation (EFI)?
EFI is a NEB initiative that identifies enzymes with unique properties and specificities that are not commercially available elsewhere. These enzymes are shared with the scientific community to enable the discovery of new and innovative applications.

What is an EFI Graduate?
An EFI graduate is an enzyme that transitions from having unknown or exploratory applications to becoming the cornerstone of a defined application.

This month, we’re proud to highlight three new EFI graduates:

TelN Protelomerase
Creates closed-ended DNA, facilitates hairpin DNA cleavage, and supports in vitro DNA template generation.
Now available in GMP-grade* formulation.

EcoGII Methyltransferase
Enables m6A methylation to mark open chromatin (e.g. RASAM**), advancing epigenetics research.

Thermostable FEN1
Removes single-stranded 5′ DNA flaps, creating ligatable ends for DNA repair workflows.

These enzymes demonstrate the impact of EFI in uncovering tools that can advance your research.

Learn More About our Enzymes for Innovation

* “GMP-grade” is a branding term NEB uses to describe products manufactured in compliance with ISO 9001 and ISO 13485 quality management system standards. However, at this time, NEB does not manufacture or sell products known as Active Pharmaceutical Ingredients (APIs), nor does NEB manufacture its products in compliance with all of the Current Good Manufacturing Practice regulations.
**Ostrowski, Megan S., et al. “The single-molecule accessibility landscape of newly replicated mammalian chromatin.” bioRxiv (2023).

Meet the NEB Team at the
ESCMID Global 2025 in Vienna

Visit ESCMID and grab the opportunity to immerse yourself in the latest topics of infectious diseases and clinical microbiology. Join leading experts, discover cutting-edge research, and meet the NEB team to discuss the latest advancements to drive your research.

ESCMID Global 2025 Vienna
11–15 April 2025

Visit NEB
at Booth C85

Learn more about
ESCMID Global 2025

Environmental Stewardship Awardees for the 2024 Passion in Science Awards advocate for more sustainable practices that benefit both science and the planet. In this blog, explore the recipients' work supporting more informed lab practices that are both cost-effective and environmentally friendly.

Find out more in our latest blog post
Promoting More Sustainable Science

Read now

Attention iGEM teams!
NEB supports your projects

iGEM is dedicated to advancing achievements in synthetic biology through education and competition, and to the development of an open, collaborative, and cooperative community that strives to find solutions for a healthier, more resilient, and sustainable world.

The Grand Jamboree brings together researchers, and other stakeholders to chart the future of synthetic biology.

NEB strives to support these values by providing the teams with first-hand tips and tricks as well as free reagents.

For further information contact your local distributor.

Contact Distributor

The brand new and updated
NEB Catalog & Technical Reference 2025/26 is coming soon!

Get inspired by the new edition of the ever-popular NEB Catalog & Technical Reference, also known as “the reference book of modern molecular biolology”, offering you

Tips and guides
Selection charts
Overview of technologies
NEB tools
Workflow descriptions
and more.

Request free copies for yourself, your students, classes, wet-lab training courses, lab group, etc. at your local distributor. Catalogs will be available in June.

At NEB, we are convinced that science should not impact the environment. That is why we make sure that all our print products are produced as sustainably as possible using recycled paper, environmentally friendly inks and bio-based PE foil. We compensate for CO₂ emissions that we currently cannot avoid.
With the production of the 2025/26 catalog, we are supporting two projects for the protection of peatlands in Germany and the transition to clean energy by women in rural India.

Request your catalog

Sustainability at NEB

New England Biolabs is a Certified B Corporation^™.